pI: 5.4831 |
Length (AA): 400 |
MW (Da): 44690 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 394 | 4f4e (A) | 1 | 399 | 36.00 | 0 | 1 | 1.5006 | -0.85 |
2 | 397 | 2cst (A) | 4 | 412 | 33.00 | 0 | 1 | 1.4516 | -0.81 |
3 | 393 | 3fsl (A) | 5 | 409 | 36.00 | 0 | 1 | 1.4881 | -0.8 |
12 | 394 | 3ii0 (A) | 15 | 410 | 36.00 | 0 | 1 | 1.4645 | -1.1 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126737)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G30970 | aspartate aminotransferase 1 |
Arabidopsis thaliana | AT5G11520 | aspartate aminotransferase 3 |
Arabidopsis thaliana | AT5G19550 | aspartate aminotransferase |
Arabidopsis thaliana | AT1G62800 | aspartate aminotransferase 4 |
Arabidopsis thaliana | AT4G31990 | aspartate aminotransferase |
Babesia bovis | BBOV_III010960 | aminotransferase, classes I and II family protein |
Brugia malayi | Bm1_30820 | aspartate aminotransferase, identical |
Candida albicans | CaO19.13666 | similar to S. cerevisiae AAT2 (YLR027C) aspartate aminotransferase, cytosolic |
Candida albicans | CaO19.6287 | similar to S. cerevisiae AAT2 (YLR027C) aspartate aminotransferase, cytosolic |
Candida albicans | CaO19.11037 | similar to mammalian mitochondrial aspartate aminotransferase |
Candida albicans | CaO19.3554 | similar to mammalian mitochondrial aspartate aminotransferase |
Caenorhabditis elegans | CELE_C44E4.3 | Protein GOT-2.1 |
Caenorhabditis elegans | CELE_T01C8.5 | Protein GOT-1.2 |
Caenorhabditis elegans | CELE_C14F11.1 | Protein GOT-2.2, isoform B |
Chlamydia trachomatis | CT_637 | aromatic amino acid aminotransferase |
Dictyostelium discoideum | DDB_G0268664 | aspartate aminotransferase |
Dictyostelium discoideum | DDB_G0282493 | aspartate aminotransferase |
Drosophila melanogaster | Dmel_CG4233 | Glutamate oxaloacetate transaminase 2 |
Drosophila melanogaster | Dmel_CG8430 | Glutamate oxaloacetate transaminase 1 |
Escherichia coli | b0928 | aspartate aminotransferase, PLP-dependent |
Escherichia coli | b4054 | tyrosine aminotransferase, tyrosine-repressible, PLP-dependent |
Echinococcus granulosus | EgrG_000778900 | aspartate aminotransferase |
Echinococcus granulosus | EgrG_001134100 | aspartate aminotransferase mitochondrial |
Echinococcus multilocularis | EmuJ_001134100 | aspartate aminotransferase, mitochondrial |
Echinococcus multilocularis | EmuJ_000778900 | aspartate aminotransferase |
Giardia lamblia | GL50803_91056 | Aspartate aminotransferase, cytoplasmic |
Homo sapiens | ENSG00000120053 | glutamic-oxaloacetic transaminase 1, soluble |
Homo sapiens | ENSG00000125166 | glutamic-oxaloacetic transaminase 2, mitochondrial |
Leishmania braziliensis | LbrM.34.0810 | aspartate aminotransferase, putative |
Leishmania braziliensis | LbrM.24.0370 | aspartate aminotransferase, putative |
Leishmania donovani | LdBPK_240370.1 | aspartate aminotransferase, putative |
Leishmania donovani | LdBPK_350840.1 | aspartate aminotransferase, putative |
Leishmania infantum | LinJ.35.0840 | aspartate aminotransferase, putative |
Leishmania infantum | LinJ.24.0370 | aspartate aminotransferase, putative |
Leishmania major | LmjF.24.0370 | aspartate aminotransferase, putative |
Leishmania major | LmjF.35.0820 | aspartate aminotransferase, putative |
Leishmania mexicana | LmxM.34.0820 | aspartate aminotransferase, putative |
Leishmania mexicana | LmxM.24.0370 | aspartate aminotransferase, putative |
Loa Loa (eye worm) | LOAG_10955 | aspartate aminotransferase |
Mus musculus | ensembl-mmu:ENSMUSG00000031672 | glutamatic-oxaloacetic transaminase 2, mitochondrial |
Mus musculus | 102643267 | aspartate aminotransferase, cytoplasmic-like |
Mus musculus | ENSMUSG00000025190 | glutamic-oxaloacetic transaminase 1, soluble |
Neospora caninum | NCLIV_064760 | Contig An16c0190, complete genome. (EC 2.6.1.1) (Precursor), related |
Oryza sativa | 4331017 | Os02g0797500 |
Oryza sativa | 4328828 | Os02g0236000 |
Oryza sativa | 4341252 | Os06g0548000 |
Oryza sativa | 4325621 | Os01g0760600 |
Plasmodium berghei | PBANKA_0302300 | aspartate aminotransferase, putative |
Plasmodium falciparum | PF3D7_0204500 | aspartate transaminase |
Plasmodium knowlesi | PKNH_0416400 | aspartate aminotransferase, putative |
Plasmodium vivax | PVX_003655 | aspartate aminotransferase, mitochondrial precursor, putative |
Plasmodium yoelii | PY00897 | aminotransferase, classes I and II, putative |
Saccharomyces cerevisiae | YKL106W | aspartate transaminase AAT1 |
Saccharomyces cerevisiae | YLR027C | aspartate transaminase AAT2 |
Schistosoma japonicum | Sjp_0212390 | Aspartate aminotransferase, cytoplasmic, putative |
Schistosoma japonicum | Sjp_0079220 | Aspartate aminotransferase, mitochondrial, putative |
Schistosoma japonicum | Sjp_0035970 | ko:K00813 aspartate aminotransferase [EC2.6.1.1B], putative |
Schistosoma mansoni | Smp_049150 | aspartate aminotransferase |
Schistosoma mansoni | Smp_064380 | branched-chain amino acid aminotransferase |
Schmidtea mediterranea | mk4.001752.02 | Aspartate aminotransferase |
Schmidtea mediterranea | mk4.001752.01 | Aspartate aminotransferase |
Schmidtea mediterranea | mk4.001208.01 | |
Schmidtea mediterranea | mk4.002005.00 | Aspartate aminotransferase, mitochondrial |
Schmidtea mediterranea | mk4.034998.00 | Aspartate aminotransferase, mitochondrial |
Trypanosoma brucei gambiense | Tbg972.10.4560 | aspartate aminotransferase, putative |
Trypanosoma brucei gambiense | Tbg972.11.5750 | aspartate aminotransferase, mitochondrial, putative |
Trypanosoma brucei | Tb927.10.3660 | aspartate aminotransferase |
Trypanosoma brucei | Tb927.11.5090 | aspartate aminotransferase, mitochondrial |
Trypanosoma congolense | TcIL3000_10_2990 | aspartate aminotransferase, putative |
Trypanosoma congolense | TcIL3000.11.5260 | aspartate aminotransferase, mitochondrial, putative |
Trypanosoma cruzi | TcCLB.503841.70 | aspartate aminotransferase, putative |
Trypanosoma cruzi | TcCLB.503679.10 | aspartate aminotransferase, putative |
Trypanosoma cruzi | TcCLB.510945.70 | aspartate aminotransferase, mitochondrial, putative |
Toxoplasma gondii | TGME49_248600 | aspartate aminotransferase |
Theileria parva | TP02_0046 | aspartate aminotransferase, putative |
Trichomonas vaginalis | TVAG_431780 | aspartate aminotransferase, putative |
Trichomonas vaginalis | TVAG_268020 | aspartate aminotransferase, putative |
Trichomonas vaginalis | TVAG_020800 | aspartate aminotransferase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.3660 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.3660 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.3660 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.3660 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb11.02.2740 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.2740 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.2740 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.02.2740 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0928 | Escherichia coli | non-essential | goodall |
b4054 | Escherichia coli | non-essential | goodall |
CELE_C44E4.3 | Caenorhabditis elegans | sterile | wormbase |
CELE_T01C8.5 | Caenorhabditis elegans | slow growth | wormbase |
YLR027C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0302300 | Plasmodium berghei | Slow | plasmo |
TGME49_248600 | Toxoplasma gondii | Probably non-essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.